2-Fluoro-N-methyl-N-({(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methyl)ethanamine

2-Fluoro-N-methyl-N-({(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methyl)ethanamine

Starting from N-methyl-1-{(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methanamine (1) target compound 2 is prepared using a mild, direct alkylation approach with 2-fluoroethyl trifluoromethanesulfonate.

Bibliographic Details
Main Authors: Catharina Neudorfer, Karem Shanab, Wolfgang Holzer, Christina Rami-Mark, Markus Mitterhauser, Wolfgang Wadsak, Helmut Spreitzer
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molbank
Subjects:
NET
PET
PHOXI
Online Access:http://www.mdpi.com/1422-8599/2015/2/M858
id doaj-bcefe151574948e59325f4c39273d3b2
record_format Article
spelling doaj-bcefe151574948e59325f4c39273d3b22020-11-24T23:01:56ZengMDPI AGMolbank1422-85992015-05-0120152M85810.3390/M858M8582-Fluoro-N-methyl-N-({(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methyl)ethanamineCatharina Neudorfer0Karem Shanab1Wolfgang Holzer2Christina Rami-Mark3Markus Mitterhauser4Wolfgang Wadsak5Helmut Spreitzer6Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDivision of Drug Synthesis, Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, AustriaDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDivision of Drug Synthesis, Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, AustriaStarting from N-methyl-1-{(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methanamine (1) target compound 2 is prepared using a mild, direct alkylation approach with 2-fluoroethyl trifluoromethanesulfonate.http://www.mdpi.com/1422-8599/2015/2/M858NETPETPHOXI
collection DOAJ
language English
format Article
sources DOAJ
author Catharina Neudorfer
Karem Shanab
Wolfgang Holzer
Christina Rami-Mark
Markus Mitterhauser
Wolfgang Wadsak
Helmut Spreitzer
spellingShingle Catharina Neudorfer
Karem Shanab
Wolfgang Holzer
Christina Rami-Mark
Markus Mitterhauser
Wolfgang Wadsak
Helmut Spreitzer
2-Fluoro-N-methyl-N-({(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methyl)ethanamine
Molbank
NET
PET
PHOXI
author_facet Catharina Neudorfer
Karem Shanab
Wolfgang Holzer
Christina Rami-Mark
Markus Mitterhauser
Wolfgang Wadsak
Helmut Spreitzer
author_sort Catharina Neudorfer
title 2-Fluoro-N-methyl-N-({(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methyl)ethanamine
title_short 2-Fluoro-N-methyl-N-({(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methyl)ethanamine
title_full 2-Fluoro-N-methyl-N-({(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methyl)ethanamine
title_fullStr 2-Fluoro-N-methyl-N-({(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methyl)ethanamine
title_full_unstemmed 2-Fluoro-N-methyl-N-({(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methyl)ethanamine
title_sort 2-fluoro-n-methyl-n-({(3s,4s)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1h-isochromen-3-yl}methyl)ethanamine
publisher MDPI AG
series Molbank
issn 1422-8599
publishDate 2015-05-01
description Starting from N-methyl-1-{(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methanamine (1) target compound 2 is prepared using a mild, direct alkylation approach with 2-fluoroethyl trifluoromethanesulfonate.
topic NET
PET
PHOXI
url http://www.mdpi.com/1422-8599/2015/2/M858
work_keys_str_mv AT catharinaneudorfer 2fluoronmethyln3s4s42trifluoromethylphenoxy34dihydro1hisochromen3ylmethylethanamine
AT karemshanab 2fluoronmethyln3s4s42trifluoromethylphenoxy34dihydro1hisochromen3ylmethylethanamine
AT wolfgangholzer 2fluoronmethyln3s4s42trifluoromethylphenoxy34dihydro1hisochromen3ylmethylethanamine
AT christinaramimark 2fluoronmethyln3s4s42trifluoromethylphenoxy34dihydro1hisochromen3ylmethylethanamine
AT markusmitterhauser 2fluoronmethyln3s4s42trifluoromethylphenoxy34dihydro1hisochromen3ylmethylethanamine
AT wolfgangwadsak 2fluoronmethyln3s4s42trifluoromethylphenoxy34dihydro1hisochromen3ylmethylethanamine
AT helmutspreitzer 2fluoronmethyln3s4s42trifluoromethylphenoxy34dihydro1hisochromen3ylmethylethanamine
_version_ 1725638295699849216

Similar Items