4-Methoxy Sulfonyl Paeonol Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis by Blocking the TGF-β1/Smad, PDGF-BB/MAPK and Akt Signaling Pathways

4-Methoxy Sulfonyl Paeonol Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis by Blocking the TGF-β1/Smad, PDGF-BB/MAPK and Akt Signaling Pathways

Liver fibrosis initiates the progression of cirrhosis, and, finally, hepatocellular carcinoma (HCC). The increased proliferation and activation of hepatic stellate cells (HSCs) are crucial for hepatic fibrogenesis. Paeonol is the major vigorous component of Cortex Moutan, a traditional herbal medici...

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Bibliographic Details
Main Authors: Yi-Jen Liao, Yuan-Hsi Wang, Chao-Lien Liu, Cheng-Chieh Fang, Ming-Hua Hsu, Fat-Moon Suk
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Applied Sciences
Subjects:
hepatic stellate cells (HSCs)
liver fibrosis
paeonol derivative
Online Access:https://www.mdpi.com/2076-3417/10/17/5941

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