The use of biologic therapies for the treatment of ocular inflammation
Purpose of review: The paper summarizes the available studies on the use, efficacy, and safety of biologic agents in the treatment of ocular inflammation. Methods: Presentation of the use of biologic agents for the treatment of ocular inflammation, with special emphasis on our experience....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Medical Association
2012-06-01
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| Series: | Zdravniški Vestnik |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/938 |
| Summary: | Purpose of review: The paper summarizes the
available studies on the use, efficacy, and safety
of biologic agents in the treatment of ocular inflammation.
Methods: Presentation of the use of biologic
agents for the treatment of ocular inflammation,
with special emphasis on our experience.
Results: Biologic agents were used in 12 patients
treated for noninfectious uveitis/scleritis in the
last 5 years. Ocular inflammatory disease was
part of systemic autoimmune disease in 11 patients,
in one the systemic disease was not established. The efficacy of biologics was good in all
patients, there were less relapses of ocular disease
and visual acuity was stable. The reactivation of
pulmonary tuberculosis and herpetic uveitis occurred
in one patient each.
Summary: Biologic therapies, especially anti-
TNF-α factor agents in the last years and interferons
show a high efficacy in controlling noninfectious
uveitis and scleritis, resistant to standard
immunosuppressants. So far, our experiences
with the use of biologics in our patients are good,
but high costs and limited long-term experience
restrict their use. |
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| ISSN: | 1318-0347 1581-0224 |