DNA Damage Inducible Transcript 4 Gene: The Switch of the Metabolism as Potential Target in Cancer

DNA Damage Inducible Transcript 4 Gene: The Switch of the Metabolism as Potential Target in Cancer

DNA damage inducible transcript 4 (DDIT4) gene is expressed under stress situations turning off the metabolic activity triggered by the mammalian target of rapamycin (mTOR). Several in vitro and in vivo works have demonstrated the ability of DDIT4 to generate resistance to cancer therapy. The link b...

Full description

Bibliographic Details
Main Authors: Indira Tirado-Hurtado, Williams Fajardo, Joseph A. Pinto
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Oncology
Subjects:
DNA damage inducible transcript 4
mammalian target of rapamycin
malignant tumors
biomarkers
targeted therapies
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2018.00106/full

Similar Items

Similar Items