CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy

CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy

Abstract Background After peripheral nerve transection, facial motoneuron (FMN) survival depends on an intact CD4+ T cell population and a central source of interleukin-10 (IL-10). However, it has not been determined previously whether CD4+ T cells participate in the central neuroprotective IL-10 ca...

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Bibliographic Details
Main Authors: Elizabeth M. Runge, Abhirami K. Iyer, Deborah O. Setter, Felicia M. Kennedy, Virginia M. Sanders, Kathryn J. Jones
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Autoimmune
Axotomy
IL-10
Motoneuron
Nerve injury
Neuroprotection
Online Access:http://link.springer.com/article/10.1186/s12974-020-01772-x

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