In vitro antioxidant capacity and free radical scavenging evaluation of standardized extract of Costus afer leaf

In vitro antioxidant capacity and free radical scavenging evaluation of standardized extract of Costus afer leaf

Absolute methanol extract leaf of Costus afer was comprehensively investigated for free radical scavenging activities and antioxidant activities using battery of testing: 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, hydroxyl radical scavenging, hydrogen peroxide radical scavenging, 2, 2′-azino-...

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Main Authors: T.G. Atere, O.A. Akinloye, R.N. Ugbaja, D.A. Ojo, G. Dealtry
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2018-12-01
Series:Food Science and Human Wellness
Online Access:http://www.sciencedirect.com/science/article/pii/S2213453017301945
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spelling doaj-bcb054876419416397b85c7c82eb04562021-02-02T03:49:47ZengKeAi Communications Co., Ltd.Food Science and Human Wellness2213-45302018-12-0174266272In vitro antioxidant capacity and free radical scavenging evaluation of standardized extract of Costus afer leafT.G. Atere0O.A. Akinloye1R.N. Ugbaja2D.A. Ojo3G. Dealtry4Department of Medical Biochemistry, College of Health Sciences, Osun State University, Osogbo, Nigeria; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria; Corresponding author at: Department of Medical Biochemistry, College of Health Sciences, Osun State University, Osogbo, Nigeria.Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaDepartment of Microbiology, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaDepartment of Biochemistry and Microbiology, Nelson Mandela Metropolitan University, Port Elizabeth, 6031, South AfricaAbsolute methanol extract leaf of Costus afer was comprehensively investigated for free radical scavenging activities and antioxidant activities using battery of testing: 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, hydroxyl radical scavenging, hydrogen peroxide radical scavenging, 2, 2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging, nitric oxide inhibition, anti-lipid peroxidation, ferrous chelating potential, reducing power potential, total antioxidant capacity, cupric reducing antioxidant capacity CUPRAC and ferric reducing antioxidant power (FRAP). The content of phenol, flavonoid, cupric, anthocyanin were also investigated. The results suggest that the antioxidant potentials of the extract may be responsible for its medicinal potentials. Cell viability assay revealed that up to12 μg/ml of the extract is safe for Chang liver cell and no sign of toxicity was observed after the extract treatment of 2000 mg/kg in albino rats. Keywords: Costus afer, Antioxidant, Toxicityhttp://www.sciencedirect.com/science/article/pii/S2213453017301945
collection DOAJ
language English
format Article
sources DOAJ
author T.G. Atere
O.A. Akinloye
R.N. Ugbaja
D.A. Ojo
G. Dealtry
spellingShingle T.G. Atere
O.A. Akinloye
R.N. Ugbaja
D.A. Ojo
G. Dealtry
In vitro antioxidant capacity and free radical scavenging evaluation of standardized extract of Costus afer leaf
Food Science and Human Wellness
author_facet T.G. Atere
O.A. Akinloye
R.N. Ugbaja
D.A. Ojo
G. Dealtry
author_sort T.G. Atere
title In vitro antioxidant capacity and free radical scavenging evaluation of standardized extract of Costus afer leaf
title_short In vitro antioxidant capacity and free radical scavenging evaluation of standardized extract of Costus afer leaf
title_full In vitro antioxidant capacity and free radical scavenging evaluation of standardized extract of Costus afer leaf
title_fullStr In vitro antioxidant capacity and free radical scavenging evaluation of standardized extract of Costus afer leaf
title_full_unstemmed In vitro antioxidant capacity and free radical scavenging evaluation of standardized extract of Costus afer leaf
title_sort in vitro antioxidant capacity and free radical scavenging evaluation of standardized extract of costus afer leaf
publisher KeAi Communications Co., Ltd.
series Food Science and Human Wellness
issn 2213-4530
publishDate 2018-12-01
description Absolute methanol extract leaf of Costus afer was comprehensively investigated for free radical scavenging activities and antioxidant activities using battery of testing: 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, hydroxyl radical scavenging, hydrogen peroxide radical scavenging, 2, 2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging, nitric oxide inhibition, anti-lipid peroxidation, ferrous chelating potential, reducing power potential, total antioxidant capacity, cupric reducing antioxidant capacity CUPRAC and ferric reducing antioxidant power (FRAP). The content of phenol, flavonoid, cupric, anthocyanin were also investigated. The results suggest that the antioxidant potentials of the extract may be responsible for its medicinal potentials. Cell viability assay revealed that up to12 μg/ml of the extract is safe for Chang liver cell and no sign of toxicity was observed after the extract treatment of 2000 mg/kg in albino rats. Keywords: Costus afer, Antioxidant, Toxicity
url http://www.sciencedirect.com/science/article/pii/S2213453017301945
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