The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation

The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation

Dopamine function is disturbed in Parkinson's disease (PD), but whether and how release of dopamine from surviving neurons is altered has long been debated. Nicotinic acetylcholine receptors (nAChRs) on dopamine axons powerfully govern dopamine release and could be critical contributing factors...

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Bibliographic Details
Main Authors: Katie A. Jennings, Nicola J. Platt, Stephanie J. Cragg
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Parkinsonian
Dopamine
Acetylcholine
Nicotinic receptors
Phasic dopamine
6-OHDA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115002338

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