Morphine decreases enteric neuron excitability via inhibition of sodium channels.

Morphine decreases enteric neuron excitability via inhibition of sodium channels.

Gastrointestinal peristalsis is significantly dependent on the enteric nervous system. Constipation due to reduced peristalsis is a major side-effect of morphine, which limits the chronic usefulness of this excellent pain reliever in man. The ionic basis for the inhibition of enteric neuron excitabi...

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Bibliographic Details
Main Authors: Tricia H Smith, John R Grider, William L Dewey, Hamid I Akbarali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3448635?pdf=render

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