Fructose Alters Intermediary Metabolism of Glucose in Human Adipocytes and Diverts Glucose to Serine Oxidation in the One–Carbon Cycle Energy Producing Pathway

Fructose Alters Intermediary Metabolism of Glucose in Human Adipocytes and Diverts Glucose to Serine Oxidation in the One–Carbon Cycle Energy Producing Pathway

Increased consumption of sugar and fructose as sweeteners has resulted in the utilization of fructose as an alternative metabolic fuel that may compete with glucose and alter its metabolism. To explore this, human Simpson-Golabi-Behmel Syndrome (SGBS) preadipocytes were differentiated to adipocytes...

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Bibliographic Details
Main Authors: Vijayalakshmi Varma, László G. Boros, Greg T. Nolen, Ching-Wei Chang, Martin Wabitsch, Richard D. Beger, Jim Kaput
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Metabolites
Subjects:
human adipocytes
fructose
glucose
[1,2-13C2]-d-glucose
targeted tracer fate association study (TTFAS)
SOGC pathway
Online Access:http://www.mdpi.com/2218-1989/5/2/364

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