Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity.

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity.

Patterns of somatic mutations in cancer genes provide information about their functional role in tumourigenesis, and thus indicate their potential for therapeutic exploitation. Yet, the classical distinction between oncogene and tumour suppressor may not always apply. For instance, TP53 has been sim...

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Bibliographic Details
Main Authors: Barbara Mair, Tomasz Konopka, Claudia Kerzendorfer, Katia Sleiman, Sejla Salic, Violeta Serra, Markus K Muellner, Vasiliki Theodorou, Sebastian M B Nijman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5010247?pdf=render

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http://europepmc.org/articles/PMC5010247?pdf=render

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