Kinetic and Microhydrodynamic Modeling of Fenofibrate Nanosuspension Production in a Wet Stirred Media Mill

Kinetic and Microhydrodynamic Modeling of Fenofibrate Nanosuspension Production in a Wet Stirred Media Mill

This study examined the impact of stirrer speed and bead material loading on fenofibrate particle breakage during wet stirred media milling (WSMM) via three kinetic models and a microhydrodynamic model. Evolution of median particle size was tracked via laser diffraction during WSMM operating at 3000...

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Bibliographic Details
Main Authors: Gulenay Guner, Dogacan Yilmaz, Ecevit Bilgili
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
poorly water-soluble drugs
wet stirred media milling
breakage kinetics
process modeling
microhydrodynamic model
statistical model
Online Access:https://www.mdpi.com/1999-4923/13/7/1055

Internet

https://www.mdpi.com/1999-4923/13/7/1055

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