The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice

The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice

The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi. In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains. Regardless of the strain used, the drug was active against a...

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Bibliographic Details
Main Authors: Danilo Ciccone Miguel, Marcela Lencine Ferraz, Rosana de Oliveira Alves, Jenicer KU Yokoyama-Yasunaka, Ana Claudia Torrecilhas, Alvaro José Romanha, Silvia RB Uliana
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2010-11-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
chemotherapy
Chagas disease
selective oestrogen receptor modulator
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000700021

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000700021

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