Impairment of gut defense barrier and microbial translocation in HIV-infection

Impairment of gut defense barrier and microbial translocation in HIV-infection

Translocation of bacterial components, including endotoxin of gram-negative microorganisms, is considered as one of the factors, contributing to hyperactivation of immune system in HIV-infection and progression of the disease. Possible reasons for increased intestinal permeability are discussed: mas...

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Bibliographic Details
Main Author: G. R. Khasanova
Format: Article
Language:Russian
Published: Journal Infectology 2014-09-01
Series:Žurnal Infektologii
Subjects:
hiv-infection
microbial translocation
activation of immune system
endotoxin
Online Access:https://journal.niidi.ru/jofin/article/view/111
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spelling doaj-bc86dcebacc64a26a23aa73db0f616662021-08-02T08:43:16ZrusJournal InfectologyŽurnal Infektologii 2072-67322014-09-0143354110.22625/2072-6732-2012-4-3-35-41125Impairment of gut defense barrier and microbial translocation in HIV-infectionG. R. Khasanova0Kazan State Medical University, KazanTranslocation of bacterial components, including endotoxin of gram-negative microorganisms, is considered as one of the factors, contributing to hyperactivation of immune system in HIV-infection and progression of the disease. Possible reasons for increased intestinal permeability are discussed: massive loss of intestinal CD4-lymphocytes, especially during acute phase of disease, significant decrease in tight junction protein expression, on-going viral replication and constant inflammation of gut mucosa, altered gut micro ecology. Results of investigations of the role of microbial translocation in progression of HIV-infection are presented.https://journal.niidi.ru/jofin/article/view/111hiv-infectionmicrobial translocationactivation of immune systemendotoxin
collection DOAJ
language Russian
format Article
sources DOAJ
author G. R. Khasanova
spellingShingle G. R. Khasanova
Impairment of gut defense barrier and microbial translocation in HIV-infection
Žurnal Infektologii
hiv-infection
microbial translocation
activation of immune system
endotoxin
author_facet G. R. Khasanova
author_sort G. R. Khasanova
title Impairment of gut defense barrier and microbial translocation in HIV-infection
title_short Impairment of gut defense barrier and microbial translocation in HIV-infection
title_full Impairment of gut defense barrier and microbial translocation in HIV-infection
title_fullStr Impairment of gut defense barrier and microbial translocation in HIV-infection
title_full_unstemmed Impairment of gut defense barrier and microbial translocation in HIV-infection
title_sort impairment of gut defense barrier and microbial translocation in hiv-infection
publisher Journal Infectology
series Žurnal Infektologii
issn 2072-6732
publishDate 2014-09-01
description Translocation of bacterial components, including endotoxin of gram-negative microorganisms, is considered as one of the factors, contributing to hyperactivation of immune system in HIV-infection and progression of the disease. Possible reasons for increased intestinal permeability are discussed: massive loss of intestinal CD4-lymphocytes, especially during acute phase of disease, significant decrease in tight junction protein expression, on-going viral replication and constant inflammation of gut mucosa, altered gut micro ecology. Results of investigations of the role of microbial translocation in progression of HIV-infection are presented.
topic hiv-infection
microbial translocation
activation of immune system
endotoxin
url https://journal.niidi.ru/jofin/article/view/111
work_keys_str_mv AT grkhasanova impairmentofgutdefensebarrierandmicrobialtranslocationinhivinfection
_version_ 1721237719972052992

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