Oral Lichen Planus: Novel Acquisitions in the Pathogenesis and Treatment

Oral Lichen Planus: Novel Acquisitions in the Pathogenesis and Treatment

Lichen planus (LP) is a mucocutaneous disease of chronic inflammatory nature, commonly seen in dermatological and dental clinics; it is a relatively common disorder of stratified squamous epithelia, frequently exclusively involving the oral cavity. Oral Lichen Planus (OLP) is often asymptomatic, the...

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Main Authors: R. Saraceno, B. Lorè, A. Ventura, S.P. Nisticò, C. Perugia, S. Chimenti, L. Bianchi
Format: Article
Language:English
Published: SAGE Publishing 2013-09-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/1721727X1301100304
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spelling doaj-bc8538a2fb42499dae85cf070f9ee7032020-11-25T02:54:19ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2013-09-011110.1177/1721727X1301100304Oral Lichen Planus: Novel Acquisitions in the Pathogenesis and TreatmentR. Saraceno0B. Lorè1A. Ventura2S.P. Nisticò3C. Perugia4S. Chimenti5L. Bianchi6 U.O.C. of Dermatology, University of Rome Tor Vergata, Rome, Italy Department of Oral and Maxillo-Facial Surgery, University of Rome Tor Vergata, Rome, Italy U.O.C. of Dermatology, University of Rome Tor Vergata, Rome, Italy Department of Dermatology, University of Catanzaro “Magna Grcecia”, Catanzaro, Italy Department of Paediatric Dentistry, University of Rome Tor Vergata, Rome, Italy U.O.C. of Dermatology, University of Rome Tor Vergata, Rome, Italy U.O.C. of Dermatology, University of Rome Tor Vergata, Rome, ItalyLichen planus (LP) is a mucocutaneous disease of chronic inflammatory nature, commonly seen in dermatological and dental clinics; it is a relatively common disorder of stratified squamous epithelia, frequently exclusively involving the oral cavity. Oral Lichen Planus (OLP) is often asymptomatic, the atrophic-erosive form can cause symptoms ranging from burning sensation to severe pain, interfering with speaking, eating, and swallowing. Lichen planus is regarded as a premalignant lesion. This review discusses the role of hepatitis C virus (HCV), bacterial and fungal infection in LP. Analysing the seroprevalence of HCV infection in LP patients and patients with oral OLP in particular, which was the case in the vast majority of studies, the association varied from 0% to 62% and seemed to be connected to the high HCV seroprevalence in the general population. Candida albicans is present in about 37% of oral LP lesions. The aim of this review is to summarize what is new in the pathogenesis and treatment of OLP.https://doi.org/10.1177/1721727X1301100304
collection DOAJ
language English
format Article
sources DOAJ
author R. Saraceno
B. Lorè
A. Ventura
S.P. Nisticò
C. Perugia
S. Chimenti
L. Bianchi
spellingShingle R. Saraceno
B. Lorè
A. Ventura
S.P. Nisticò
C. Perugia
S. Chimenti
L. Bianchi
Oral Lichen Planus: Novel Acquisitions in the Pathogenesis and Treatment
European Journal of Inflammation
author_facet R. Saraceno
B. Lorè
A. Ventura
S.P. Nisticò
C. Perugia
S. Chimenti
L. Bianchi
author_sort R. Saraceno
title Oral Lichen Planus: Novel Acquisitions in the Pathogenesis and Treatment
title_short Oral Lichen Planus: Novel Acquisitions in the Pathogenesis and Treatment
title_full Oral Lichen Planus: Novel Acquisitions in the Pathogenesis and Treatment
title_fullStr Oral Lichen Planus: Novel Acquisitions in the Pathogenesis and Treatment
title_full_unstemmed Oral Lichen Planus: Novel Acquisitions in the Pathogenesis and Treatment
title_sort oral lichen planus: novel acquisitions in the pathogenesis and treatment
publisher SAGE Publishing
series European Journal of Inflammation
issn 1721-727X
publishDate 2013-09-01
description Lichen planus (LP) is a mucocutaneous disease of chronic inflammatory nature, commonly seen in dermatological and dental clinics; it is a relatively common disorder of stratified squamous epithelia, frequently exclusively involving the oral cavity. Oral Lichen Planus (OLP) is often asymptomatic, the atrophic-erosive form can cause symptoms ranging from burning sensation to severe pain, interfering with speaking, eating, and swallowing. Lichen planus is regarded as a premalignant lesion. This review discusses the role of hepatitis C virus (HCV), bacterial and fungal infection in LP. Analysing the seroprevalence of HCV infection in LP patients and patients with oral OLP in particular, which was the case in the vast majority of studies, the association varied from 0% to 62% and seemed to be connected to the high HCV seroprevalence in the general population. Candida albicans is present in about 37% of oral LP lesions. The aim of this review is to summarize what is new in the pathogenesis and treatment of OLP.
url https://doi.org/10.1177/1721727X1301100304
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