Individualized treatment based on single-nucleotide polymorphisms with tacrolimus in ulcerative colitis

Individualized treatment based on single-nucleotide polymorphisms with tacrolimus in ulcerative colitis

Background/Aims The pharmacokinetics of tacrolimus (TAC) is known to be largely influenced by single-nucleotide polymorphisms (SNPs) in CYP3A5. Patients starting TAC require careful dose adjustment, owing to the wide range of optimal dosages, depending on their CYP3A5 expression status. Here, we eva...

Full description

Bibliographic Details
Main Authors: Shinji Okabayashi, Taku Kobayashi, Eiko Saito, Takahiko Toyonaga, Ryo Ozaki, Shintaro Sagami, Masaru Nakano, Junichi Tanaka, Keiji Yagisawa, Satoshi Kuronuma, Osamu Takeuchi, Toshifumi Hibi
Format: Article
Language:English
Published: Korean Association for the Study of Intestinal Diseases 2019-04-01
Series:Intestinal Research
Subjects:
Colitis, ulcerative
Tacrolimus
Individualized treatment
Online Access:http://www.irjournal.org/upload/pdf/ir-2018-00117.pdf

Similar Items

Similar Items