On-line coupling of derivatization with pre-concentration to determine trace levels of methotrexate

On-line coupling of derivatization with pre-concentration to determine trace levels of methotrexate

A new simple, sensitive and precise green analytical procedure using an automated packed-reactor derivatization technique coupled with on-line solid-phase enrichment (SPEn) has been developed and evaluated to determine trace levels of methotrexate (MTX). The method was based on injection of MTX into...

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Bibliographic Details
Main Authors: Samy Emara, Tsutomu Masujima, Walaa Zarad, Maha Kamal, Ramzia EL-Bagary
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Journal of Pharmaceutical Analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177912001190

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