Functional evaluation indicates physical losses after hematopoietic stem cell transplantation

OBJECTIVE: To perform a function evaluation of patients before and after hematopoietic stem cell transplantation. METHODS: From November 2008 to November 2010, 29 female (58%) and 21 male patients (42%) with median age of 48 years (range: 24-67) were enrolled in this study. Data collection was perfo...

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Main Authors: Clarissa Vasconcellos de Souza, Eliana Cristina Martins Miranda, Celso Garcia Jr, Francisco José Penteado Aranha, Cármino Antonio de Souza, Afonso Celso Vigorito
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Revista Brasileira de Hematologia e Hemoterapia
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000500010
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spelling doaj-bc789be971714cf59ad6ea4f3c5517482020-11-24T20:46:17ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1516-84841806-08702012-01-0134534535110.5581/1516-8484.20120090Functional evaluation indicates physical losses after hematopoietic stem cell transplantationClarissa Vasconcellos de SouzaEliana Cristina Martins MirandaCelso Garcia JrFrancisco José Penteado AranhaCármino Antonio de SouzaAfonso Celso VigoritoOBJECTIVE: To perform a function evaluation of patients before and after hematopoietic stem cell transplantation. METHODS: From November 2008 to November 2010, 29 female (58%) and 21 male patients (42%) with median age of 48 years (range: 24-67) were enrolled in this study. Data collection was performed before and after autologous or allogeneic hematopoietic stem cell transplantation. Evaluation instruments included the 2-minute walking test to evaluate gait performance with assessment of the oxygen saturation, heart rate and Borg Scale before and after the test; grip strength for strength evaluation, Schober Test for spine mobility testing and maximum and adapted activity scores of the Human Activity Profile questionnaire to test functionality in daily activities. RESULTS: Fifty patients were evaluated at baseline; six did not undergo hematopoietic stem cell transplantation (three died, one refused and two were excluded). Thus 44/50 (88% - 21 allogeneic and 23 autologous) transplantations were performed. Only 33 of the 44 patients (75%) performed evaluations after transplantation (nine died and two were excluded). Of the patients who performed both evaluations, significantly lower values were found in the evaluation after transplantation for the 2-minute walking test (p-value = 0.004), grip strength of both right and left hands (p-value = 0.004 and p-value < 0.0001, respectively), the Schober Test, and maximum and adapted activity scores (p-value < 0.0001). The heart rate was higher (p-value = 0.01) before the 2-minute walking test and oxygen saturation was higher (p-value = 0.02) after. CONCLUSION: Statistical differences indicate functional impairment after transplantation showing physical losses in this population.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000500010RehabilitationPhysical examinationHematopoietic stem cell transplantation
collection DOAJ
language English
format Article
sources DOAJ
author Clarissa Vasconcellos de Souza
Eliana Cristina Martins Miranda
Celso Garcia Jr
Francisco José Penteado Aranha
Cármino Antonio de Souza
Afonso Celso Vigorito
spellingShingle Clarissa Vasconcellos de Souza
Eliana Cristina Martins Miranda
Celso Garcia Jr
Francisco José Penteado Aranha
Cármino Antonio de Souza
Afonso Celso Vigorito
Functional evaluation indicates physical losses after hematopoietic stem cell transplantation
Revista Brasileira de Hematologia e Hemoterapia
Rehabilitation
Physical examination
Hematopoietic stem cell transplantation
author_facet Clarissa Vasconcellos de Souza
Eliana Cristina Martins Miranda
Celso Garcia Jr
Francisco José Penteado Aranha
Cármino Antonio de Souza
Afonso Celso Vigorito
author_sort Clarissa Vasconcellos de Souza
title Functional evaluation indicates physical losses after hematopoietic stem cell transplantation
title_short Functional evaluation indicates physical losses after hematopoietic stem cell transplantation
title_full Functional evaluation indicates physical losses after hematopoietic stem cell transplantation
title_fullStr Functional evaluation indicates physical losses after hematopoietic stem cell transplantation
title_full_unstemmed Functional evaluation indicates physical losses after hematopoietic stem cell transplantation
title_sort functional evaluation indicates physical losses after hematopoietic stem cell transplantation
publisher Elsevier
series Revista Brasileira de Hematologia e Hemoterapia
issn 1516-8484
1806-0870
publishDate 2012-01-01
description OBJECTIVE: To perform a function evaluation of patients before and after hematopoietic stem cell transplantation. METHODS: From November 2008 to November 2010, 29 female (58%) and 21 male patients (42%) with median age of 48 years (range: 24-67) were enrolled in this study. Data collection was performed before and after autologous or allogeneic hematopoietic stem cell transplantation. Evaluation instruments included the 2-minute walking test to evaluate gait performance with assessment of the oxygen saturation, heart rate and Borg Scale before and after the test; grip strength for strength evaluation, Schober Test for spine mobility testing and maximum and adapted activity scores of the Human Activity Profile questionnaire to test functionality in daily activities. RESULTS: Fifty patients were evaluated at baseline; six did not undergo hematopoietic stem cell transplantation (three died, one refused and two were excluded). Thus 44/50 (88% - 21 allogeneic and 23 autologous) transplantations were performed. Only 33 of the 44 patients (75%) performed evaluations after transplantation (nine died and two were excluded). Of the patients who performed both evaluations, significantly lower values were found in the evaluation after transplantation for the 2-minute walking test (p-value = 0.004), grip strength of both right and left hands (p-value = 0.004 and p-value < 0.0001, respectively), the Schober Test, and maximum and adapted activity scores (p-value < 0.0001). The heart rate was higher (p-value = 0.01) before the 2-minute walking test and oxygen saturation was higher (p-value = 0.02) after. CONCLUSION: Statistical differences indicate functional impairment after transplantation showing physical losses in this population.
topic Rehabilitation
Physical examination
Hematopoietic stem cell transplantation
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000500010
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