Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques.

Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques.

BACKGROUND: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors. However, such models do not predict involvement of P2Y(12) in the clinically relevant situation of...

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Main Authors: Reyhan Nergiz-Unal, Judith M E M Cosemans, Marion A H Feijge, Paola E J van der Meijden, Robert F Storey, J J J van Giezen, Mirjam G A oude Egbrink, Johan W M Heemskerk, Marijke J E Kuijpers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2853564?pdf=render

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