Investigation of Subclinical Cardiotoxicity in Chronic Leukemia Patients with Non-invasive Tests

Introduction:This study aimed to investigate the left ventricular function and electrocardiographic findings in patients with chronic leukemia receiving and not receiving chemotherapy during a one-year follow-up.Methods:A total of 111 patients with chronic leukemia were included in the study. Electr...

Full description

Bibliographic Details
Main Authors: Timor Omar, Rasim Enar, Barış İkitimur, Burçak Kılıçkıran Avcı
Format: Article
Language:English
Published: Galenos Yayinevi 2019-11-01
Series:İstanbul Medical Journal
Subjects:
Online Access: http://imj.galenos.com.tr/archives/archive-detail/article-preview/nvestigation-of-subclinical-cardiotoxicity-in-chro/31949
id doaj-bc5b7fc82ba54ffd9b24e7ae5a2cd4e9
record_format Article
spelling doaj-bc5b7fc82ba54ffd9b24e7ae5a2cd4e92020-11-24T21:39:51ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2019-11-0120652853410.4274/imj.galenos.2019.0973413049054Investigation of Subclinical Cardiotoxicity in Chronic Leukemia Patients with Non-invasive TestsTimor Omar0Rasim Enar1Barış İkitimur2Burçak Kılıçkıran Avcı3 Kars Harakani State Hospital, Clinic of Cardiology, Kars, Turkey İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Cardiology, İstanbul, Turkey İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Cardiology, İstanbul, Turkey İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Cardiology, İstanbul, Turkey Introduction:This study aimed to investigate the left ventricular function and electrocardiographic findings in patients with chronic leukemia receiving and not receiving chemotherapy during a one-year follow-up.Methods:A total of 111 patients with chronic leukemia were included in the study. Electrocardiographic and mechanical findings of the heart were evaluated by surface 12-lead electrocardiogram and 2-dimensional transthoracic echocardiography, and cardiac troponin (cTn) was evaluated for myocyte damage and B-type natriuretic peptide marker for heart failure at baseline, 6th month and 12th month.Results:During the study, a total of six patients reached the endpoint, including two patients to primary endpoint (atrial fibrillation) and four patients to secondary endpoint (non-cardiac death). However, asymptomatic hemodynamic and electrocardiographic changes were observed in all patients who did not reach the endpoint. There was a quantitative decrease in left ventricular ejection fraction and an increase in the rate of diastolic dysfunction. Increased incidence of fragmented QRS, and prolongation of QT interval and QT dispersion, which are important indicators of possible cardiac events, were detected. cTn levels were observed to be at the upper limit of the normal range. All these findings show that myocardial damage has begun in the study patients, even if it is asymptomatic.Conclusion:In order to prevent future cardiac events in this patient group, these changes need to be taken into consideration and closely monitored. http://imj.galenos.com.tr/archives/archive-detail/article-preview/nvestigation-of-subclinical-cardiotoxicity-in-chro/31949 chronic leukemiaheart failurecardiotoxicity
collection DOAJ
language English
format Article
sources DOAJ
author Timor Omar
Rasim Enar
Barış İkitimur
Burçak Kılıçkıran Avcı
spellingShingle Timor Omar
Rasim Enar
Barış İkitimur
Burçak Kılıçkıran Avcı
Investigation of Subclinical Cardiotoxicity in Chronic Leukemia Patients with Non-invasive Tests
İstanbul Medical Journal
chronic leukemia
heart failure
cardiotoxicity
author_facet Timor Omar
Rasim Enar
Barış İkitimur
Burçak Kılıçkıran Avcı
author_sort Timor Omar
title Investigation of Subclinical Cardiotoxicity in Chronic Leukemia Patients with Non-invasive Tests
title_short Investigation of Subclinical Cardiotoxicity in Chronic Leukemia Patients with Non-invasive Tests
title_full Investigation of Subclinical Cardiotoxicity in Chronic Leukemia Patients with Non-invasive Tests
title_fullStr Investigation of Subclinical Cardiotoxicity in Chronic Leukemia Patients with Non-invasive Tests
title_full_unstemmed Investigation of Subclinical Cardiotoxicity in Chronic Leukemia Patients with Non-invasive Tests
title_sort investigation of subclinical cardiotoxicity in chronic leukemia patients with non-invasive tests
publisher Galenos Yayinevi
series İstanbul Medical Journal
issn 2619-9793
2148-094X
publishDate 2019-11-01
description Introduction:This study aimed to investigate the left ventricular function and electrocardiographic findings in patients with chronic leukemia receiving and not receiving chemotherapy during a one-year follow-up.Methods:A total of 111 patients with chronic leukemia were included in the study. Electrocardiographic and mechanical findings of the heart were evaluated by surface 12-lead electrocardiogram and 2-dimensional transthoracic echocardiography, and cardiac troponin (cTn) was evaluated for myocyte damage and B-type natriuretic peptide marker for heart failure at baseline, 6th month and 12th month.Results:During the study, a total of six patients reached the endpoint, including two patients to primary endpoint (atrial fibrillation) and four patients to secondary endpoint (non-cardiac death). However, asymptomatic hemodynamic and electrocardiographic changes were observed in all patients who did not reach the endpoint. There was a quantitative decrease in left ventricular ejection fraction and an increase in the rate of diastolic dysfunction. Increased incidence of fragmented QRS, and prolongation of QT interval and QT dispersion, which are important indicators of possible cardiac events, were detected. cTn levels were observed to be at the upper limit of the normal range. All these findings show that myocardial damage has begun in the study patients, even if it is asymptomatic.Conclusion:In order to prevent future cardiac events in this patient group, these changes need to be taken into consideration and closely monitored.
topic chronic leukemia
heart failure
cardiotoxicity
url http://imj.galenos.com.tr/archives/archive-detail/article-preview/nvestigation-of-subclinical-cardiotoxicity-in-chro/31949
work_keys_str_mv AT timoromar investigationofsubclinicalcardiotoxicityinchronicleukemiapatientswithnoninvasivetests
AT rasimenar investigationofsubclinicalcardiotoxicityinchronicleukemiapatientswithnoninvasivetests
AT barısikitimur investigationofsubclinicalcardiotoxicityinchronicleukemiapatientswithnoninvasivetests
AT burcakkılıckıranavcı investigationofsubclinicalcardiotoxicityinchronicleukemiapatientswithnoninvasivetests
_version_ 1725928805018632192