Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children

<p>Abstract</p> <p>Background</p> <p>Coeliac disease is a chronic intestinal inflammatory disorder due to an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first lin...

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Main Authors: Calabuig Miguel, Ribes-Koninckx Carmen, Donat Ester, Medina Marcela, Nadal Inmaculada, De Palma Giada, Sanz Yolanda
Format: Article
Language:English
Published: BMC 2010-02-01
Series:BMC Microbiology
Online Access:http://www.biomedcentral.com/1471-2180/10/63
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spelling doaj-bc59f76548bd4fe187211cf04c3126112020-11-24T20:53:40ZengBMCBMC Microbiology1471-21802010-02-011016310.1186/1471-2180-10-63Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in childrenCalabuig MiguelRibes-Koninckx CarmenDonat EsterMedina MarcelaNadal InmaculadaDe Palma GiadaSanz Yolanda<p>Abstract</p> <p>Background</p> <p>Coeliac disease is a chronic intestinal inflammatory disorder due to an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition of faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls.</p> <p>Results</p> <p>IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. <it>Bifidobacterium</it>, <it>Clostridium histolyticum</it>, <it>C. lituseburense </it>and <it>Faecalibacterium prausnitzii </it>group proportions were less abundant (<it>P </it>< 0.050) in untreated CD patients than in healthy controls. <it>Bacteroides-Prevotella </it>group proportions were more abundant (<it>P </it>< 0.050) in untreated CD patients than in controls. Levels of IgA coating the <it>Bacteroides-Prevotella </it>group were significantly reduced (<it>P </it>< 0.050) in both CD patients in comparison with healthy controls.</p> <p>Conclusions</p> <p>In CD patients, reduced IgA-coated bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.</p> http://www.biomedcentral.com/1471-2180/10/63
collection DOAJ
language English
format Article
sources DOAJ
author Calabuig Miguel
Ribes-Koninckx Carmen
Donat Ester
Medina Marcela
Nadal Inmaculada
De Palma Giada
Sanz Yolanda
spellingShingle Calabuig Miguel
Ribes-Koninckx Carmen
Donat Ester
Medina Marcela
Nadal Inmaculada
De Palma Giada
Sanz Yolanda
Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
BMC Microbiology
author_facet Calabuig Miguel
Ribes-Koninckx Carmen
Donat Ester
Medina Marcela
Nadal Inmaculada
De Palma Giada
Sanz Yolanda
author_sort Calabuig Miguel
title Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
title_short Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
title_full Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
title_fullStr Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
title_full_unstemmed Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
title_sort intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
publisher BMC
series BMC Microbiology
issn 1471-2180
publishDate 2010-02-01
description <p>Abstract</p> <p>Background</p> <p>Coeliac disease is a chronic intestinal inflammatory disorder due to an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition of faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls.</p> <p>Results</p> <p>IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. <it>Bifidobacterium</it>, <it>Clostridium histolyticum</it>, <it>C. lituseburense </it>and <it>Faecalibacterium prausnitzii </it>group proportions were less abundant (<it>P </it>< 0.050) in untreated CD patients than in healthy controls. <it>Bacteroides-Prevotella </it>group proportions were more abundant (<it>P </it>< 0.050) in untreated CD patients than in controls. Levels of IgA coating the <it>Bacteroides-Prevotella </it>group were significantly reduced (<it>P </it>< 0.050) in both CD patients in comparison with healthy controls.</p> <p>Conclusions</p> <p>In CD patients, reduced IgA-coated bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.</p>
url http://www.biomedcentral.com/1471-2180/10/63
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