Agonal Factors Distort Gene-Expression Patterns in Human Postmortem Brains

Agonal Factors Distort Gene-Expression Patterns in Human Postmortem Brains

Agonal factors, the conditions that occur just prior to death, can impact the molecular quality of postmortem brains, influencing gene expression results. Our study used gene expression data of 262 samples from ROSMAP with the detailed terminal state recorded for each donor, such as fever, infection...

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Bibliographic Details
Main Authors: Jiacheng Dai, Yu Chen, Rujia Dai, Yi Jiang, Jianghua Tian, Sihan Liu, Meng Xu, Miao Li, Jiaqi Zhou, Chunyu Liu, Chao Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neuroscience
Subjects:
agonal factors
post-mortem brain studies
gene expression
gene co-expression
brain cell types
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.614142/full

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