Increased PD-1+Tim-3+ exhausted T cells in bone marrow may influence the clinical outcome of patients with AML

Increased PD-1+Tim-3+ exhausted T cells in bone marrow may influence the clinical outcome of patients with AML

Abstract Background Altered expression of T cell immune inhibitory receptors may result in immunosuppression and associate with the poor prognosis of leukemia patients in which the leukemic bone marrow (BM) microenvironment may contribute to such immunosuppression. We found higher numbers of program...

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Bibliographic Details
Main Authors: Jiaxiong Tan, Zhi Yu, Jingying Huang, Youchun Chen, Shuxin Huang, Danlin Yao, Ling Xu, Yuhong Lu, Shaohua Chen, Yangqiu Li
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Biomarker Research
Subjects:
AML
T cell exhaustion
T cell subset
PD-1
Tim-3
Online Access:https://doi.org/10.1186/s40364-020-0185-8

Internet

https://doi.org/10.1186/s40364-020-0185-8

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