Further Evidence That Defects in Main Thyroid Dysgenesis-Related Genes Are an Uncommon Etiology for Primary Congenital Hypothyroidism in Mexican Patients: Report of Rare Variants in <i>FOXE1</i>, <i>NKX2-5</i> and <i>TSHR</i>

Further Evidence That Defects in Main Thyroid Dysgenesis-Related Genes Are an Uncommon Etiology for Primary Congenital Hypothyroidism in Mexican Patients: Report of Rare Variants in <i>FOXE1</i>, <i>NKX2-5</i> and <i>TSHR</i>

Mexico shows a high birth prevalence of congenital hypothyroidism (CH) due to thyroid dysgenesis (TD). <i>PAX8</i> defects underlie only 1% of these cases and <i>NKX2-1</i> does not seem to be involved. Here, we analyzed other TD-related genes in 128 non-related Mexican patie...

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Bibliographic Details
Main Authors: Miguel Angel Alcántara-Ortigoza, Iraís Sánchez-Verdiguel, Liliana Fernández-Hernández, Sergio Enríquez-Flores, Aidy González-Núñez, Nancy Leticia Hernández-Martínez, Carmen Sánchez, Ariadna González-del Angel
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Children
Subjects:
congenital hypothyroidism
<i>FOXE1</i>
Mexican population
multiplex ligation-dependent probe amplification (MLPA)
<i>NKX2-1</i>
<i>NKX2-5</i>
Online Access:https://www.mdpi.com/2227-9067/8/6/457

Internet

https://www.mdpi.com/2227-9067/8/6/457

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