A novel angiopoietin-2 selective fully human antibody with potent anti-tumoral and anti-angiogenic efficacy and superior side effect profile compared to Pan-Angiopoietin-1/-2 inhibitors.

A novel angiopoietin-2 selective fully human antibody with potent anti-tumoral and anti-angiogenic efficacy and superior side effect profile compared to Pan-Angiopoietin-1/-2 inhibitors.

There is increasing experimental evidence for an important role of Angiopoietin-2 (Ang-2) in tumor angiogenesis and progression. In addition, Ang-2 is up-regulated in many cancer types and correlated with poor prognosis. To investigate the functional role of Ang-2 inhibition in tumor development and...

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Bibliographic Details
Main Authors: Markus Thomas, Yvonne Kienast, Werner Scheuer, Monika Bähner, Klaus Kaluza, Christian Gassner, Frank Herting, Ulrich Brinkmann, Stefan Seeber, Anita Kavlie, Martin Welschof, Stefan Ries, K Michael Weidner, Jörg T Regula, Christian Klein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3566157?pdf=render

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