Microwave enhanced green and convenient synthesis of 2-amino-4H-chromenes in aqueous hydrotropic medium

• Main Authors: Pramod Gaikwad, Santosh Kamble
• Format: Article
• Language: English
• Published: Elsevier 2020-06-01
• Series: Current Research in Green and Sustainable Chemistry
• Subjects: Microwave; Aqueous hydrotropic medium; Green synthesis; 2-amino-4H-chromenes; 2-amino-4H-chromenes.ave
• Online Access: http://www.sciencedirect.com/science/article/pii/S2666086520300175

Microwave enhanced one pot three component synthesis of 2-amino-4H-chromenes in aqueous hydrotropic medium is reported. The aqueous hydrotropic medium represents a green solvent under microwave irradiation. The synthetic methdology under microwave irradiation is renewable and sustainable tool of energy saveing. The number of different aromatic aldehydes was condensed with malononitrile and α-Naphthol or β-Naphthol in aqueous hydrotropic medium under microwave irradiation gives different derivatives of 2-amino-4H-chromenes obtained in good to excellent yield. This exhibits environmentally benign methodology with simple experimental and work up procedure. The significant features of this methods are shorter reaction time, non-toxic, reusable, inexpensive, biodegradable and high yield of product.