Panax notoginseng saponins increases the blood concentration of nifedipine by inhibiting CYP3A4 enzyme through PXR- and CAR-Mediated pathway

Panax notoginseng saponins increases the blood concentration of nifedipine by inhibiting CYP3A4 enzyme through PXR- and CAR-Mediated pathway

Objective: To explore the mechanism underlying the effect of Panax notoginseng saponins (PNS) on the pharmacokinetics of nifedipine (NF) in rats. Materials and Methods: Twenty-four rats were randomly divided into blank (BL) group, PNS group, NF group, and PNS + NF group, with six rats in each group....

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Bibliographic Details
Main Authors: Qiu-Hong Li, Jiao Zhao, Ai-Xia Ju, Yong Hu, Qing-Song Qie, Hong-Bin Xiao, Guang Xu, Xi-Jun Wang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:World Journal of Traditional Chinese Medicine
Subjects:
car
cyp3a4
nifedipine
panax notoginseng saponins
pharmacokinetics
pxr
Online Access:http://www.wjtcm.net/article.asp?issn=2311-8571;year=2021;volume=7;issue=3;spage=332;epage=338;aulast=Li

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http://www.wjtcm.net/article.asp?issn=2311-8571;year=2021;volume=7;issue=3;spage=332;epage=338;aulast=Li

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