Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”

Abstract Maintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmaco...

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Main Authors:	Daniel Agustin Godoy, Rafael Badenes, Paolo Pelosi, Chiara Robba
Format:	Article
Language:	English
Published:	BMC 2021-01-01
Series:	Critical Care
Subjects:	Ketamine Traumatic brain injury Sedation Agitation Secondary insult Cooperative sedation
Online Access:	https://doi.org/10.1186/s13054-020-03452-x

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spelling	doaj-bc160e2b22ff48b585cbaecae2118d9a2021-01-10T12:29:47ZengBMCCritical Care1364-85352021-01-012511710.1186/s13054-020-03452-xKetamine in acute phase of severe traumatic brain injury “an old drug for new uses?”Daniel Agustin Godoy0Rafael Badenes1Paolo Pelosi2Chiara Robba3Neurointensive Care Unit, Sanatorio PasteurAnesthesiology and Surgical-Trauma Intensive Care, University Clinic HospitalAnesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and NeurosciencesAnesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and NeurosciencesAbstract Maintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.https://doi.org/10.1186/s13054-020-03452-xKetamineTraumatic brain injurySedationAgitationSecondary insultCooperative sedation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Daniel Agustin Godoy Rafael Badenes Paolo Pelosi Chiara Robba
spellingShingle	Daniel Agustin Godoy Rafael Badenes Paolo Pelosi Chiara Robba Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?” Critical Care Ketamine Traumatic brain injury Sedation Agitation Secondary insult Cooperative sedation
author_facet	Daniel Agustin Godoy Rafael Badenes Paolo Pelosi Chiara Robba
author_sort	Daniel Agustin Godoy
title	Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
title_short	Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
title_full	Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
title_fullStr	Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
title_full_unstemmed	Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
title_sort	ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
publisher	BMC
series	Critical Care
issn	1364-8535
publishDate	2021-01-01
description	Abstract Maintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.
topic	Ketamine Traumatic brain injury Sedation Agitation Secondary insult Cooperative sedation
url	https://doi.org/10.1186/s13054-020-03452-x
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Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”

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