Electrical activity controls area-specific expression of neuronal apoptosis in the mouse developing cerebral cortex

Electrical activity controls area-specific expression of neuronal apoptosis in the mouse developing cerebral cortex

Programmed cell death widely but heterogeneously affects the developing brain, causing the loss of up to 50% of neurons in rodents. However, whether this heterogeneity originates from neuronal identity and/or network-dependent processes is unknown. Here, we report that the primary motor cortex (M1)...

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Bibliographic Details
Main Authors: Oriane Blanquie, Jenq-Wei Yang, Werner Kilb, Salim Sharopov, Anne Sinning, Heiko J Luhmann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
cerebral cortex
activity patterns
apoptosis
cell death
development
whisker deafferentation
Online Access:https://elifesciences.org/articles/27696

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