Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries

Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries

<p>Abstract</p> <p>Background</p> <p>Src plays various roles in tumour progression, invasion, metastasis, angiogenesis and survival. It is one of the multiple targets of multi-target kinase inhibitors in clinical uses and trials for the treatment of leukemia and other c...

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Bibliographic Details
Main Authors: Han Bucong, Ma Xiaohua, Zhao Ruiying, Zhang Jingxian, Wei Xiaona, Liu Xianghui, Liu Xin, Zhang Cunlong, Tan Chunyan, Jiang Yuyang, Chen Yuzong
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Chemistry Central Journal
Subjects:
Src
c-src
Computer aided drug design
Kinase inhibitor
Virtual screening
Support vector machine
Online Access:http://journal.chemistrycentral.com/content/6/1/139

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http://journal.chemistrycentral.com/content/6/1/139

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