Influence of Defined Hydrophilic Blocks within Oligoaminoamide Copolymers: Compaction versus Shielding of pDNA Nanoparticles

Influence of Defined Hydrophilic Blocks within Oligoaminoamide Copolymers: Compaction versus Shielding of pDNA Nanoparticles

Cationic polymers are promising components of the versatile platform of non-viral nucleic acid (NA) delivery agents. For a successful gene delivery system, these NA vehicles need to comprise several functionalities. This work focuses on the modification of oligoaminoamide carriers with hydrophilic o...

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Bibliographic Details
Main Authors: Stephan Morys, Ana Krhac Levacic, Sarah Urnauer, Susanne Kempter, Sarah Kern, Joachim O. Rädler, Christine Spitzweg, Ulrich Lächelt, Ernst Wagner
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:Polymers
Subjects:
complex stability
nanoparticle
oligoamine
nucleic acid delivery
plasmid DNA (pDNA)
polyethylene glycol (PEG)
polyplex
shielding
Online Access:http://www.mdpi.com/2073-4360/9/4/142

Internet

http://www.mdpi.com/2073-4360/9/4/142

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