Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers

Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers

Abstract An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes, including proliferation, apoptosis, migration, invasion, chromatin remodeling, metabolism and immune escape. Clinically, the expression of MIR22HG is increased i...

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Main Authors: Le Zhang, Cuixia Li, Xiulan Su
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Long noncoding RNAs
MIR22HG
Tumorigenesis
Therapeutic target
Online Access:https://doi.org/10.1186/s13046-020-01784-8
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spelling doaj-bbeeea82d2964bb7a788967f990445d42020-12-06T12:06:18ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662020-12-0139111210.1186/s13046-020-01784-8Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancersLe Zhang0Cuixia Li1Xiulan Su2Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical UniversityClinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical UniversityClinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical UniversityAbstract An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes, including proliferation, apoptosis, migration, invasion, chromatin remodeling, metabolism and immune escape. Clinically, the expression of MIR22HG is increased in many human tumors (colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, and thyroid carcinoma), while in others (esophageal adenocarcinoma and glioblastoma), it is significantly decreased. Moreover, MIR22HG has been reported to function as a competitive endogenous RNA (ceRNA), be involved in signaling pathways, interact with proteins and interplay with miRNAs as a host gene to participate in tumorigenesis and tumor progression. In this review, we describe the biological functions of MIR22HG, reveal its underlying mechanisms for cancer regulation, and highlight the potential role of MIR22HG as a novel cancer prognostic biomarker and therapeutic target that can increase the efficacy of immunotherapy and targeted therapy for cancer treatment.https://doi.org/10.1186/s13046-020-01784-8Long noncoding RNAsMIR22HGTumorigenesisTherapeutic target
collection DOAJ
language English
format Article
sources DOAJ
author Le Zhang
Cuixia Li
Xiulan Su
spellingShingle Le Zhang
Cuixia Li
Xiulan Su
Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers
Journal of Experimental & Clinical Cancer Research
Long noncoding RNAs
MIR22HG
Tumorigenesis
Therapeutic target
author_facet Le Zhang
Cuixia Li
Xiulan Su
author_sort Le Zhang
title Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers
title_short Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers
title_full Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers
title_fullStr Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers
title_full_unstemmed Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers
title_sort emerging impact of the long noncoding rna mir22hg on proliferation and apoptosis in multiple human cancers
publisher BMC
series Journal of Experimental & Clinical Cancer Research
issn 1756-9966
publishDate 2020-12-01
description Abstract An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes, including proliferation, apoptosis, migration, invasion, chromatin remodeling, metabolism and immune escape. Clinically, the expression of MIR22HG is increased in many human tumors (colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, and thyroid carcinoma), while in others (esophageal adenocarcinoma and glioblastoma), it is significantly decreased. Moreover, MIR22HG has been reported to function as a competitive endogenous RNA (ceRNA), be involved in signaling pathways, interact with proteins and interplay with miRNAs as a host gene to participate in tumorigenesis and tumor progression. In this review, we describe the biological functions of MIR22HG, reveal its underlying mechanisms for cancer regulation, and highlight the potential role of MIR22HG as a novel cancer prognostic biomarker and therapeutic target that can increase the efficacy of immunotherapy and targeted therapy for cancer treatment.
topic Long noncoding RNAs
MIR22HG
Tumorigenesis
Therapeutic target
url https://doi.org/10.1186/s13046-020-01784-8
work_keys_str_mv AT lezhang emergingimpactofthelongnoncodingrnamir22hgonproliferationandapoptosisinmultiplehumancancers
AT cuixiali emergingimpactofthelongnoncodingrnamir22hgonproliferationandapoptosisinmultiplehumancancers
AT xiulansu emergingimpactofthelongnoncodingrnamir22hgonproliferationandapoptosisinmultiplehumancancers
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