Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8

Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8

Schwann cells (SCs) can acquire a repair phenotype following nerve injury. Here, the authors show that stromal SCs in ganglioneuromas express nerve-repair genes. Importantly, neuroblastoma cells respond to repair-related SCs increasing neuronal differentiation and reducing proliferation via EGFL8.

Bibliographic Details
Main Authors: Tamara Weiss, Sabine Taschner-Mandl, Lukas Janker, Andrea Bileck, Fikret Rifatbegovic, Florian Kromp, Helena Sorger, Maximilian O. Kauer, Christian Frech, Reinhard Windhager, Christopher Gerner, Peter F. Ambros, Inge M. Ambros
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21859-0
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spelling doaj-bbebc8510b0142cda49d7e4b7259747d2021-03-14T12:07:20ZengNature Publishing GroupNature Communications2041-17232021-03-0112111910.1038/s41467-021-21859-0Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8Tamara Weiss0Sabine Taschner-Mandl1Lukas Janker2Andrea Bileck3Fikret Rifatbegovic4Florian Kromp5Helena Sorger6Maximilian O. Kauer7Christian Frech8Reinhard Windhager9Christopher Gerner10Peter F. Ambros11Inge M. Ambros12St. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)Department of Analytical Chemistry, University of ViennaDepartment of Analytical Chemistry, University of ViennaSt. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)Department of Orthopedic Surgery, Medical University of ViennaDepartment of Analytical Chemistry, University of ViennaSt. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)Schwann cells (SCs) can acquire a repair phenotype following nerve injury. Here, the authors show that stromal SCs in ganglioneuromas express nerve-repair genes. Importantly, neuroblastoma cells respond to repair-related SCs increasing neuronal differentiation and reducing proliferation via EGFL8.https://doi.org/10.1038/s41467-021-21859-0
collection DOAJ
language English
format Article
sources DOAJ
author Tamara Weiss
Sabine Taschner-Mandl
Lukas Janker
Andrea Bileck
Fikret Rifatbegovic
Florian Kromp
Helena Sorger
Maximilian O. Kauer
Christian Frech
Reinhard Windhager
Christopher Gerner
Peter F. Ambros
Inge M. Ambros
spellingShingle Tamara Weiss
Sabine Taschner-Mandl
Lukas Janker
Andrea Bileck
Fikret Rifatbegovic
Florian Kromp
Helena Sorger
Maximilian O. Kauer
Christian Frech
Reinhard Windhager
Christopher Gerner
Peter F. Ambros
Inge M. Ambros
Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
Nature Communications
author_facet Tamara Weiss
Sabine Taschner-Mandl
Lukas Janker
Andrea Bileck
Fikret Rifatbegovic
Florian Kromp
Helena Sorger
Maximilian O. Kauer
Christian Frech
Reinhard Windhager
Christopher Gerner
Peter F. Ambros
Inge M. Ambros
author_sort Tamara Weiss
title Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
title_short Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
title_full Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
title_fullStr Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
title_full_unstemmed Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
title_sort schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-03-01
description Schwann cells (SCs) can acquire a repair phenotype following nerve injury. Here, the authors show that stromal SCs in ganglioneuromas express nerve-repair genes. Importantly, neuroblastoma cells respond to repair-related SCs increasing neuronal differentiation and reducing proliferation via EGFL8.
url https://doi.org/10.1038/s41467-021-21859-0
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