Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
Schwann cells (SCs) can acquire a repair phenotype following nerve injury. Here, the authors show that stromal SCs in ganglioneuromas express nerve-repair genes. Importantly, neuroblastoma cells respond to repair-related SCs increasing neuronal differentiation and reducing proliferation via EGFL8.
Bibliographic Details
| Main Authors: |
Tamara Weiss,
Sabine Taschner-Mandl,
Lukas Janker,
Andrea Bileck,
Fikret Rifatbegovic,
Florian Kromp,
Helena Sorger,
Maximilian O. Kauer,
Christian Frech,
Reinhard Windhager,
Christopher Gerner,
Peter F. Ambros,
Inge M. Ambros |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-21859-0
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