CD8+ T Cell Exhaustion in Cancer

CD8+ T Cell Exhaustion in Cancer

A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is underway. Originally thought to be a uniform population that progressively loses effector function in response to persistent antigen, single-cell analysis has now revealed that CD8+ Tex is composed of multiple interc...

Full description

Bibliographic Details
Main Authors:	Joseph S. Dolina, Natalija Van Braeckel-Budimir, Graham D. Thomas, Shahram Salek-Ardakani
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-07-01
Series:	Frontiers in Immunology
Subjects:	T cell exhaustion PD-1/PD-L1 T cell trafficking tumor immunity cancer immunotherapy CXCR3
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.715234/full

Similar Items

Exploring Markers of Exhausted CD8 T Cells to Predict Response to Immune Checkpoint Inhibitor Therapy for Hepatocellular Carcinoma
by: Chia-Lang Hsu, et al.
Published: (2021-05-01)

Cellular and Molecular Mechanisms of CD8<sup>+</sup> T Cell Differentiation, Dysfunction and Exhaustion
by: Daniel J. Verdon, et al.
Published: (2020-10-01)

T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses
by: Alireza Saeidi, et al.
Published: (2018-11-01)

Single-cell transcriptome analysis reveals TOX as a promoting factor for T cell exhaustion and a predictor for anti-PD-1 responses in human cancer
by: Kyungsoo Kim, et al.
Published: (2020-02-01)

miR-149-3p reverses CD8+ T-cell exhaustion by reducing inhibitory receptors and promoting cytokine secretion in breast cancer cells
by: Meng Zhang, et al.
Published: (2019-10-01)

Downregulation of CD73 associates with T cell exhaustion in AML patients
by: Yaxian Kong, et al.
Published: (2019-04-01)

Phenotypic Evidence of T Cell Exhaustion and Senescence During Symptomatic Plasmodium falciparum Malaria
by: Augustina Frimpong, et al.
Published: (2019-06-01)

PD-L1 Overexpression, SWI/SNF Complex Deregulation, and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4<sup>+</sup> T Cells
by: Iga Jancewicz, et al.
Published: (2021-08-01)

Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation
by: Ricardo A. León-Letelier, et al.
Published: (2020-11-01)

Human papilloma virus load and PD-1/PD-L1, CD8+ and FOXP3 in anal cancer patients treated with chemoradiotherapy: Rationale for immunotherapy
by: Panagiotis Balermpas, et al.
Published: (2017-03-01)

Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes
by: Christina P. Martins, et al.
Published: (2021-06-01)

Evaluation of Exhausted Regulatory T Cells in Preeclampsia
by: Nahid Daraei, et al.
Published: (2019-06-01)

Platelet Induced Functional Alteration of CD4<sup>+</sup> and CD8<sup>+</sup> T Cells in HNSCC
by: Christina Polasky, et al.
Published: (2020-10-01)

Editorial: T Cell Exhaustion
by: Cristina Bonorino, et al.
Published: (2020-06-01)

Lymphopenia-induced proliferation of CD4 T-cells is associated with CD4 T-lymphocyte exhaustion in treated HIV-infected patients
by: Evgeniya V Saidakova, et al.
Published: (2018-01-01)

Increased PD-1+Tim-3+ exhausted T cells in bone marrow may influence the clinical outcome of patients with AML
by: Jiaxiong Tan, et al.
Published: (2020-02-01)

Advances of PD-1/PD-L1 Inhibitors in Tumor Immunotherapy
by: Yong-jun LIU, et al.
Published: (2017-06-01)

PD-L1/PD-1 crosstalk in colorectal cancer: are we targeting the right cells?
by: Ramón Cantero-Cid, et al.
Published: (2018-10-01)

CD4+ T Cells are Exhausted and Show Functional Defects in Chronic Lymphocytic Leukemia
by: Esmaeil Allahmoradi, et al.
Published: (2017-12-01)

Editorial: Memory T Cells in Chronic Infections and Tumors
by: Maike Hofmann, et al.
Published: (2021-02-01)

Reversal of the CD8+ T-Cell Exhaustion Induced by Chronic HIV-1 Infection Through Combined Blockade of the Adenosine and PD-1 Pathways
by: Jing Li, et al.
Published: (2021-06-01)

Moving forward to address key unanswered questions on targeting PD-1/PD-L1 in cancer: limitations in preclinical models and the need to incorporate human modifying factors
by: Catherine T. Le, et al.
Published: (2019-11-01)

Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch
by: Wen Juan Tu, et al.
Published: (2020-06-01)

Tumor cells versus host immune cells: whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy?
by: Fei Tang, et al.
Published: (2018-05-01)

Upregulation of PD-L1 Expression by Prostaglandin E2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection
by: Shinya Goto, et al.
Published: (2020-02-01)

Memory T cell, exhaustion, and tumor immunity
by: Makoto Ando, et al.
Published: (2020-01-01)

Modern approaches to kidney cancer immunotherapy
by: N. E. Kushlinskii, et al.
Published: (2018-07-01)

Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy
by: Daixi Ren, et al.
Published: (2020-01-01)

The Role of PD-1 in Acute and Chronic Infection
by: Jil M. Jubel, et al.
Published: (2020-03-01)

Inactivation of the PD-1-dependent immunoregulation in mice exacerbates contact hypersensitivity resembling immune-related adverse events
by: Ashoori, Matin Dokht
Published: (2021)

Monitoring Patient Response to Pembrolizumab With Peripheral Blood Exhaustion Marker Profiles
by: Moira Graves, et al.
Published: (2019-05-01)

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection
by: Yean K. Yong, et al.
Published: (2018-03-01)

Preclinical Rationale for Targeting the PD-1/PD-L1 Axis in Combination with a CD38 Antibody in Multiple Myeloma and Other CD38-Positive Malignancies
by: Christie P. M. Verkleij, et al.
Published: (2020-12-01)

Different Expression Characteristics of LAG3 and PD-1 in Sepsis and Their Synergistic Effect on T Cell Exhaustion: A New Strategy for Immune Checkpoint Blockade
by: Bailin Niu, et al.
Published: (2019-08-01)

Cancer immunotherapies targeting the PD-1 signaling pathway
by: Yoshiko Iwai, et al.
Published: (2017-04-01)

Checkpoint Inhibition in Myeloma: Opportunities and Challenges
by: Federica Costa, et al.
Published: (2018-09-01)

Nobel committee honors tumor immunologists
by: Anand Rotte, et al.
Published: (2018-10-01)

Application and Prospects of Molecular Imaging in Immunotherapy
by: Wang W, et al.
Published: (2020-09-01)

A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects
by: Wei-Yun Lai, et al.
Published: (2016-01-01)

Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4+ T cells tolerized by peptide immunotherapy
by: Rhoanne C McPherson, et al.
Published: (2014-12-01)

Cannot write session to /tmp/vufind_sessions/sess_0hialmqittutse3473oovg5bqm