Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod

Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod

Alzheimer's disease (AD) induces time-dependent changes in sphingolipid metabolism, which may affect transcription regulation and neuronal phenotype. We, therefore, analyzed the influence of age, amyloid β precursor protein (AβPP), and the clinically approved, bioavailable sphingosine-1-phospha...

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Bibliographic Details
Main Authors: Henryk Jęśko, Iga Wieczorek, Przemysław Leonard Wencel, Magdalena Gąssowska-Dobrowolska, Walter J. Lukiw, Robert Piotr Strosznajder
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
aging
Alzheimer's disease
amyloid β
FTY720/fingolimod
neurodegeneration
sphingolipids
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.660104/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2021.660104/full

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