Impact of oxidative posttranslational modifications of SERCA2 on heart failure exacerbation in young patients with non-ischemic cardiomyopathy: A pilot study

Impact of oxidative posttranslational modifications of SERCA2 on heart failure exacerbation in young patients with non-ischemic cardiomyopathy: A pilot study

Background: Oxidative posttranslational modifications (OPTM) impair the function of Sarcoplasmic/endoplasmic reticulum (SR) calcium (Ca2+) ATPase (SERCA) 2 and trigger cytosolic Ca2+ dysregulation. We investigated the extent of OPTM of SERCA2 in patients with non-ischemic cardiomyopathy (NICM). Meth...

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Bibliographic Details
Main Authors: Takumi Toya, Kei Ito, Kazuki Kagami, Ayumu Osaki, Atsushi Sato, Toyokazu Kimura, Shunpei Horii, Risako Yasuda, Takayuki Namba, Yasuo Ido, Yuji Nagatomo, Katsumi Hayashi, Nobuyuki Masaki, Hirotaka Yada, Takeshi Adachi
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:International Journal of Cardiology: Heart & Vasculature
Online Access:http://www.sciencedirect.com/science/article/pii/S2352906719301848

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http://www.sciencedirect.com/science/article/pii/S2352906719301848

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