Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers

Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers

Extracellular vesicles (EVs), such as exosomes, are critical mediators of intercellular communication between tumor cells and other cells located in the microenvironment but also in more distant sites. Exosomes are small EVs that can carry a variety of molecules, such as lipids, proteins, and non-co...

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Main Authors: Lyna Kara-Terki, Lucas Treps, Christophe Blanquart, Delphine Fradin
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
exosome
mesothelioma
lung cancer
miRNA
Online Access:https://www.mdpi.com/1422-0067/21/17/6024
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spelling doaj-bbd8f0398e594dcba4f6b6f7e2fda5e62020-11-25T03:14:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-01216024602410.3390/ijms21176024Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic CancersLyna Kara-Terki0Lucas Treps1Christophe Blanquart2Delphine Fradin3CRCINA, INSERM, Université de Nantes, F-44000 Nantes, FranceCRCINA, INSERM, Université de Nantes, F-44000 Nantes, FranceCRCINA, INSERM, Université de Nantes, F-44000 Nantes, FranceCRCINA, INSERM, Université de Nantes, F-44000 Nantes, FranceExtracellular vesicles (EVs), such as exosomes, are critical mediators of intercellular communication between tumor cells and other cells located in the microenvironment but also in more distant sites. Exosomes are small EVs that can carry a variety of molecules, such as lipids, proteins, and non-coding RNA, especially microRNAs (miRNAs). In thoracic cancers, including lung cancers and malignant pleural mesothelioma, EVs contribute to the immune-suppressive tumor microenvironment and to tumor growth and metastasis. In this review, we discuss the recent understanding of how exosomes behave in thoracic cancers and how and why they are promising liquid biomarkers for diagnosis, prognosis, and therapy, with a special focus on exosomal miRNAs.https://www.mdpi.com/1422-0067/21/17/6024exosomemesotheliomalung cancermiRNA
collection DOAJ
language English
format Article
sources DOAJ
author Lyna Kara-Terki
Lucas Treps
Christophe Blanquart
Delphine Fradin
spellingShingle Lyna Kara-Terki
Lucas Treps
Christophe Blanquart
Delphine Fradin
Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers
International Journal of Molecular Sciences
exosome
mesothelioma
lung cancer
miRNA
author_facet Lyna Kara-Terki
Lucas Treps
Christophe Blanquart
Delphine Fradin
author_sort Lyna Kara-Terki
title Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers
title_short Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers
title_full Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers
title_fullStr Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers
title_full_unstemmed Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers
title_sort critical roles of tumor extracellular vesicles in the microenvironment of thoracic cancers
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2020-08-01
description Extracellular vesicles (EVs), such as exosomes, are critical mediators of intercellular communication between tumor cells and other cells located in the microenvironment but also in more distant sites. Exosomes are small EVs that can carry a variety of molecules, such as lipids, proteins, and non-coding RNA, especially microRNAs (miRNAs). In thoracic cancers, including lung cancers and malignant pleural mesothelioma, EVs contribute to the immune-suppressive tumor microenvironment and to tumor growth and metastasis. In this review, we discuss the recent understanding of how exosomes behave in thoracic cancers and how and why they are promising liquid biomarkers for diagnosis, prognosis, and therapy, with a special focus on exosomal miRNAs.
topic exosome
mesothelioma
lung cancer
miRNA
url https://www.mdpi.com/1422-0067/21/17/6024
work_keys_str_mv AT lynakaraterki criticalrolesoftumorextracellularvesiclesinthemicroenvironmentofthoraciccancers
AT lucastreps criticalrolesoftumorextracellularvesiclesinthemicroenvironmentofthoraciccancers
AT christopheblanquart criticalrolesoftumorextracellularvesiclesinthemicroenvironmentofthoraciccancers
AT delphinefradin criticalrolesoftumorextracellularvesiclesinthemicroenvironmentofthoraciccancers
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