Feedback-Driven Mechanisms Between Phosphorylated Caveolin-1 and Contractile Actin Assemblies Instruct Persistent Cell Migration

Feedback-Driven Mechanisms Between Phosphorylated Caveolin-1 and Contractile Actin Assemblies Instruct Persistent Cell Migration

The actin cytoskeleton and membrane-associated caveolae contribute to active processes, such as cell morphogenesis and motility. How these two systems interact and control directional cell migration is an outstanding question but remains understudied. Here we identified a negative feedback between c...

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Bibliographic Details
Main Authors: Xuemeng Shi, Zeyu Wen, Yajun Wang, Yan-Jun Liu, Kun Shi, Yaming Jiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
actin filaments
actomyosin bundles
Arp2/3 complex-dependent lamellipodia
directional cell migration
caveolin-1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.665919/full

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