Caffeic acid reduces body weight by regulating gut microbiota in diet-induced-obese mice

Caffeic acid reduces body weight by regulating gut microbiota in diet-induced-obese mice

Caffeic acid (CFA), a natural polyphenolic compound which exists in coffee, fruits and certain traditional Chinese medicine, is one promising anti-obesity agent with a variety of pharmacological activities. The objective of the current study was to determine the mechanism of anti-obesity effect of C...

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Main Authors: Jia Xu, Jianbing Ge, Xiaoyun He, Yao Sheng, Shujuan Zheng, Chuanhai Zhang, Wentao Xu, Kunlun Huang
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Journal of Functional Foods
Subjects:
Caffeic acid
Microbiota
Obesity
DIO mice
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464620302851
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spelling doaj-bbca88a5d6df45fc8f3ff7220e6081002021-04-30T07:19:16ZengElsevierJournal of Functional Foods1756-46462020-11-0174104061Caffeic acid reduces body weight by regulating gut microbiota in diet-induced-obese miceJia Xu0Jianbing Ge1Xiaoyun He2Yao Sheng3Shujuan Zheng4Chuanhai Zhang5Wentao Xu6Kunlun Huang7Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCorresponding author at: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua East Road, Beijing 100083, China.; Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCaffeic acid (CFA), a natural polyphenolic compound which exists in coffee, fruits and certain traditional Chinese medicine, is one promising anti-obesity agent with a variety of pharmacological activities. The objective of the current study was to determine the mechanism of anti-obesity effect of CFA, and the relationship between its anti-obesity effect and gut microbiota change in high fat diet induced obese (DIO) mice. The DIO mice were administrated CFA by daily gavage at 50 mg/kg body weight for 12 weeks. The results showed that CFA significantly ameliorated high fat diet induced obesity. Specifically CFA reduced body weight and fat accumulation, improved lipid profile and increased energy expenditure in DIO mice. Moreover, CFA restored gut microbiota imbalance and increased the abundance of anti-obesity related bacteria and butyrate-producing bacteria in DIO mice. We conclude that CFA is effective to reduce metabolic risks possibly by regulating gut microbiota.http://www.sciencedirect.com/science/article/pii/S1756464620302851Caffeic acidMicrobiotaObesityDIO mice
collection DOAJ
language English
format Article
sources DOAJ
author Jia Xu
Jianbing Ge
Xiaoyun He
Yao Sheng
Shujuan Zheng
Chuanhai Zhang
Wentao Xu
Kunlun Huang
spellingShingle Jia Xu
Jianbing Ge
Xiaoyun He
Yao Sheng
Shujuan Zheng
Chuanhai Zhang
Wentao Xu
Kunlun Huang
Caffeic acid reduces body weight by regulating gut microbiota in diet-induced-obese mice
Journal of Functional Foods
Caffeic acid
Microbiota
Obesity
DIO mice
author_facet Jia Xu
Jianbing Ge
Xiaoyun He
Yao Sheng
Shujuan Zheng
Chuanhai Zhang
Wentao Xu
Kunlun Huang
author_sort Jia Xu
title Caffeic acid reduces body weight by regulating gut microbiota in diet-induced-obese mice
title_short Caffeic acid reduces body weight by regulating gut microbiota in diet-induced-obese mice
title_full Caffeic acid reduces body weight by regulating gut microbiota in diet-induced-obese mice
title_fullStr Caffeic acid reduces body weight by regulating gut microbiota in diet-induced-obese mice
title_full_unstemmed Caffeic acid reduces body weight by regulating gut microbiota in diet-induced-obese mice
title_sort caffeic acid reduces body weight by regulating gut microbiota in diet-induced-obese mice
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2020-11-01
description Caffeic acid (CFA), a natural polyphenolic compound which exists in coffee, fruits and certain traditional Chinese medicine, is one promising anti-obesity agent with a variety of pharmacological activities. The objective of the current study was to determine the mechanism of anti-obesity effect of CFA, and the relationship between its anti-obesity effect and gut microbiota change in high fat diet induced obese (DIO) mice. The DIO mice were administrated CFA by daily gavage at 50 mg/kg body weight for 12 weeks. The results showed that CFA significantly ameliorated high fat diet induced obesity. Specifically CFA reduced body weight and fat accumulation, improved lipid profile and increased energy expenditure in DIO mice. Moreover, CFA restored gut microbiota imbalance and increased the abundance of anti-obesity related bacteria and butyrate-producing bacteria in DIO mice. We conclude that CFA is effective to reduce metabolic risks possibly by regulating gut microbiota.
topic Caffeic acid
Microbiota
Obesity
DIO mice
url http://www.sciencedirect.com/science/article/pii/S1756464620302851
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