Supplementation of beef extract improves chemotherapy-induced fatigue and toxic effects in mice

• Main Authors: Tsung-Hsien Hsu, Shao-Wen Hung, Chun-Yun Wu, Chien-Chao Chiu, Hsin-Tai Hong, Guo-Chi Lee, Chia-Chi Chen, Jyh-Shiun Lin, Chean-Ping Wu
• Format: Article
• Language: English
• Published: Elsevier 2020-12-01
• Series: Journal of Functional Foods
• Subjects: Beef extract; Chemotherapy; Fatigue; Antioxidant enzymes
• Online Access: http://www.sciencedirect.com/science/article/pii/S1756464620304564

Physiological fatigue and toxic effects are commonly associated with chemotherapy. Beef extract (BE) is a nutritional supplement obtained by cooking beef. The present study examined the effects of several BE concentrations on 5-fluorouracil (5-FU)-induced fatigue and toxic effects in mice. Results showed BE supplementation ameliorated 5-FU-induced body and organ weight loss. All BE + 5-FU groups demonstrated increased grip strength (135.3–163.2 g), endurance time (567.3–911.3 s), and movement distance (23623–31225 cm) when compared with the 5-FU group (97.6 g, 265.2 s, and 13916 cm). Hepatic and muscular (0.76 and 1.06 mg/g) glycogen levels were maintained in the BE-3x + 5-FU group when compared with the 5-FU group (0.44 and 0.58 mg/g). Moreover, catalase (liver and muscle) and glutathione peroxidase (liver) activities were enhanced. The serum alanine aminotransferase, aspartate aminotransferase, and histopathological changes were ameliorated in the BE-2x + 5-FU and BE-3x + 5-FU groups. BE supplementation could provide a novel strategy for managing 5-FU-induced fatigue and toxic effects.