Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons

Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons

Misonidazole (MISO) was considered as radiosensitizer for the treatment of hypoxic tumors. A prerequisite for entering a hypoxic cell is reduction of the drug, which may occur in the early physical-chemical stage of radiation damage. Here we study electron attachment to MISO and find that it very ef...

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Bibliographic Details
Main Authors: Rebecca Meißner, Linda Feketeová, Eugen Illenberger, Stephan Denifl
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
electron attachment
misonidazole
radiosensitizer
mass spectrometry
fragmentation
nitroimidazoles
reduction
Online Access:https://www.mdpi.com/1422-0067/20/14/3496

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