Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis

Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis

<p>Abstract</p> <p>Background</p> <p>Recent studies suggest the potential benefits of statins as anti-cancer agents. Mechanisms by which statins induce apoptosis in cancer cells are not clear. We previously showed that simvastatin inhibit prostate cancer cell functions...

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Bibliographic Details
Main Authors: Goc Anna, Kochuparambil Samith T, Al-Husein Belal, Al-Azayzih Ahmad, Mohammad Shuaib, Somanath Payaningal R
Format: Article
Language:English
Published: BMC 2012-09-01
Series:BMC Cancer
Subjects:
Prostate cancer
Simvastatin
Docetaxel
Apoptosis
Bcl-2
Fas-L
Online Access:http://www.biomedcentral.com/1471-2407/12/409

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