Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes

Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes

Despite combined antiretroviral therapy (ART) achieving efficient HIV replication control, HIV-associated neurocognitive disorders (HAND) continue to be highly prevalent in HIV-infected patients. Diabetes mellitus (DM) is a well-known comorbidity of HAND in HIV-infected patients. Blood brain barrier...

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Bibliographic Details
Main Authors: Slava Rom, Sachin Gajghate, Malika Winfield, Nancy L. Reichenbach, Yuri Persidsky
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
BBB
diabetes
HIV-1
hyperglycemia
endothelial dysfunction
actin cytoskeleton rearrangement
Online Access:https://www.mdpi.com/1422-0067/21/13/4663

Internet

https://www.mdpi.com/1422-0067/21/13/4663

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