The Paralogous Genes PDR18 and SNQ2, Encoding Multidrug Resistance ABC Transporters, Derive From a Recent Duplication Event, PDR18 Being Specific to the Saccharomyces Genus

The Paralogous Genes PDR18 and SNQ2, Encoding Multidrug Resistance ABC Transporters, Derive From a Recent Duplication Event, PDR18 Being Specific to the Saccharomyces Genus

Pleiotropic drug resistance (PDR) family of ATP-binding cassette (ABC) transporters play a key role in the simultaneous acquisition of resistance to a wide range of structurally and functionally unrelated cytotoxic compounds in yeasts. Saccharomyces cerevisiae Pdr18 was proposed to transport ergoste...

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Bibliographic Details
Main Authors: Cláudia P. Godinho, Paulo J. Dias, Elise Ponçot, Isabel Sá-Correia
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Genetics
Subjects:
ABC transporters
PDR18 and SNQ2
phylogenetic and genomic neighborhood analyzes
comparative genomics and evolution
multidrug resistance
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00476/full

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