Stroma-Rich Co-Culture Multicellular Tumor Spheroids as a Tool for Photoactive Drugs Screening

Stroma-Rich Co-Culture Multicellular Tumor Spheroids as a Tool for Photoactive Drugs Screening

Conventional 3D multicellular tumor spheroids of head and neck squamous cell carcinoma (HNSCC) consisting exclusively of cancer cells have some limitations. They are compact cell aggregates that do not interact with their extracellular milieu, thus suffering from both insufficient extracellular matr...

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Bibliographic Details
Main Authors: Ilya Yakavets, Samuel Jenard, Aurelie Francois, Yulia Maklygina, Victor Loschenov, Henri-Pierre Lassalle, Gilles Dolivet, Lina Bezdetnaya
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Journal of Clinical Medicine
Subjects:
photodynamic therapy
temoporfin
head and neck squamous carcinoma
multicellular tumor spheroids
cancer-associated fibroblasts
drug penetration
Online Access:https://www.mdpi.com/2077-0383/8/10/1686

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https://www.mdpi.com/2077-0383/8/10/1686

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