Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells

Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells

Brain development: Specifying differentiation into midbrain cells An evolutionarily conserved signaling pathway triggers the differentiation of human pluripotent stem cells (hPSCs) into functional midbrain neurons. Dong-Wook Kim at Yonsei University, South Korea, and colleagues explored the mechanis...

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Bibliographic Details
Main Authors: Ji Young Kim, Jae Souk Lee, Hyun Sub Hwang, Dongjin R. Lee, Chul-Yong Park, Sung Jun Jung, Young Rang You, Dae-Sung Kim, Dong-Wook Kim
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-018-0044-y

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