Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast

Whereas wild-type strains of Saccharomyces cerevisiae can synthesize up to 7% dry weight of ergosterol, a polyene-resistant mutant has been obtained which produces no ergosterol. Instead, a C-28 methyl sterol is produced, and it has been identified as Δ8(9),22-ergostadiene-3β-ol. This sterol is conv...

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Main Authors:	L.W. Parks, F.T. Bond, E.D. Thompson, P.R. Starr
Format:	Article
Language:	English
Published:	Elsevier 1972-05-01
Series:	Journal of Lipid Research
Subjects:	ergosterol sterol mutant yeast sterol polyene resistance
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520393925

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spelling	doaj-bb9f086348a947f2b77cfa99bc1a14cb2021-04-24T05:51:35ZengElsevierJournal of Lipid Research0022-22751972-05-01133311316Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeastL.W. Parks0F.T. Bond1E.D. Thompson2P.R. Starr3Department of Microbiology, Oregon State University, Corvallis, Oregon 97331; and; Department of Chemistry, Revelle College, University of California at San Diego, LaJolla, California 92037Department of Microbiology, Oregon State University, Corvallis, Oregon 97331; and; Department of Chemistry, Revelle College, University of California at San Diego, LaJolla, California 92037Department of Microbiology, Oregon State University, Corvallis, Oregon 97331; and; Department of Chemistry, Revelle College, University of California at San Diego, LaJolla, California 92037Department of Microbiology, Oregon State University, Corvallis, Oregon 97331; and; Department of Chemistry, Revelle College, University of California at San Diego, LaJolla, California 92037Whereas wild-type strains of Saccharomyces cerevisiae can synthesize up to 7% dry weight of ergosterol, a polyene-resistant mutant has been obtained which produces no ergosterol. Instead, a C-28 methyl sterol is produced, and it has been identified as Δ8(9),22-ergostadiene-3β-ol. This sterol is converted to ergosterol by wild-type yeasts and is observed transiently in cells during aerobic adaption of anaerobically grown wild-type yeasts. The new sterol is proposed as an intermediate in ergosterol biosynthesis.http://www.sciencedirect.com/science/article/pii/S0022227520393925ergosterolsterol mutantyeast sterolpolyene resistance
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	L.W. Parks F.T. Bond E.D. Thompson P.R. Starr
spellingShingle	L.W. Parks F.T. Bond E.D. Thompson P.R. Starr Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast Journal of Lipid Research ergosterol sterol mutant yeast sterol polyene resistance
author_facet	L.W. Parks F.T. Bond E.D. Thompson P.R. Starr
author_sort	L.W. Parks
title	Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast
title_short	Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast
title_full	Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast
title_fullStr	Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast
title_full_unstemmed	Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast
title_sort	δ8(9),22-ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast
publisher	Elsevier
series	Journal of Lipid Research
issn	0022-2275
publishDate	1972-05-01
description	Whereas wild-type strains of Saccharomyces cerevisiae can synthesize up to 7% dry weight of ergosterol, a polyene-resistant mutant has been obtained which produces no ergosterol. Instead, a C-28 methyl sterol is produced, and it has been identified as Δ8(9),22-ergostadiene-3β-ol. This sterol is converted to ergosterol by wild-type yeasts and is observed transiently in cells during aerobic adaption of anaerobically grown wild-type yeasts. The new sterol is proposed as an intermediate in ergosterol biosynthesis.
topic	ergosterol sterol mutant yeast sterol polyene resistance
url	http://www.sciencedirect.com/science/article/pii/S0022227520393925
work_keys_str_mv	AT lwparks d8922ergostadiene3bolanergosterolprecursoraccumulatedinwildtypeandmutantsofyeast AT ftbond d8922ergostadiene3bolanergosterolprecursoraccumulatedinwildtypeandmutantsofyeast AT edthompson d8922ergostadiene3bolanergosterolprecursoraccumulatedinwildtypeandmutantsofyeast AT prstarr d8922ergostadiene3bolanergosterolprecursoraccumulatedinwildtypeandmutantsofyeast
_version_	1721511737872613376

Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast

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