Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast

Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast

Whereas wild-type strains of Saccharomyces cerevisiae can synthesize up to 7% dry weight of ergosterol, a polyene-resistant mutant has been obtained which produces no ergosterol. Instead, a C-28 methyl sterol is produced, and it has been identified as Δ8(9),22-ergostadiene-3β-ol. This sterol is conv...

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Bibliographic Details
Main Authors: L.W. Parks, F.T. Bond, E.D. Thompson, P.R. Starr
Format: Article
Language:English
Published: Elsevier 1972-05-01
Series:Journal of Lipid Research
Subjects:
ergosterol
sterol mutant
yeast sterol
polyene resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520393925
Description
Summary:Whereas wild-type strains of Saccharomyces cerevisiae can synthesize up to 7% dry weight of ergosterol, a polyene-resistant mutant has been obtained which produces no ergosterol. Instead, a C-28 methyl sterol is produced, and it has been identified as Δ8(9),22-ergostadiene-3β-ol. This sterol is converted to ergosterol by wild-type yeasts and is observed transiently in cells during aerobic adaption of anaerobically grown wild-type yeasts. The new sterol is proposed as an intermediate in ergosterol biosynthesis.
ISSN:0022-2275

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