PKC, AKT and ERK1/2-Mediated Modulations of PARP1, NF-κB and PEA15 Activities Distinctly Regulate Regional Specific Astroglial Responses Following Status Epilepticus

PKC, AKT and ERK1/2-Mediated Modulations of PARP1, NF-κB and PEA15 Activities Distinctly Regulate Regional Specific Astroglial Responses Following Status Epilepticus

Status epilepticus (SE, a prolonged seizure activity) leads to reactive astrogliosis and astroglial apoptosis in the regional specific manners, independent of hemodynamics. Poly(ADP-ribose) polymerase-1 (PARP1) activity is relevant to these distinct astroglial responses. Since various regulatory sig...

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Bibliographic Details
Main Authors: Ji-Eun Kim, Tae-Cheon Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
3CAI
BIM
epilepsy
KN-93
PJ-34
SC79
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00180/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00180/full

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