Rescue of Cyclic AMP mediated long term potentiation impairment in the hippocampus of Mecp2 knockout (Mecp2-/y) mice by rolipram

Rescue of Cyclic AMP mediated long term potentiation impairment in the hippocampus of Mecp2 knockout (Mecp2-/y) mice by rolipram

Rett syndrome (RTT) patients experience learning difficulties and memory loss. Analogous deficits of hippocampal plasticity are reported in mouse models of RTT. To elucidate the underlying pathophysiology, we studied long term potentiation (LTP) at the CA3 to CA1 synapses in the hippocampus in acute...

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Bibliographic Details
Main Authors: Saju eBalakrishnan, Marcus eNiebert, Diethelm eRichter
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Forskolin
Memory
plasticity
patch clamp
adenylyl cyclase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00015/full

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